ABSTRACT

Cancer is the second leading cause of death, and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 death is due to cancer. Colorectal cancer is the fourth most commonly diagnosed cancer in American men as well as women and is the third leading cause of cancer deaths among them. Current methods for treatment such as chemotherapy have their limitations due to their toxic effects on non-targeted tissues furthering human health problems. Therefore, there is a demand for alternative treatments with naturallyderived anticancer agents with plants being the desired source. The Clerodendron viscosum V. leaves & Macrotyloma uniflorum L seeds are the traditionally important medicinal plants but still there is no scientific evidence for anticancer activity. So, present research is aimed to exploration of anticancer activity of Clerodendron viscosum V. leaves & Macrotyloma uniflorum L seeds. The anticancer activity was evaluated by using MTT cytotoxicity assay against Human colorectal carcinoma cell line. The hydro-ethanol extracts of Clerodendron viscosum V. leaves & Macrotyloma uniflorum L were studied at different concentrations against HCT-116 cell line using MTT cytotoxicity assay. Results indicated that, the both plant extracts were given good anticancer activity against HCT-116 cell line. Between both the plant extracts, hydro ethanolic extract of Macrotyloma uniflorum L seeds showed higher cytotoxicity potential in human colon cancer cell line, the activity of this extract might due to the presence of active constituents such as flavonoids especially Quercetin and alkaloids. Keywords: HCT-116, Antitumor, Cytotoxicity, MTT, Quercetin
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5183.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5183