ABSTRACT

Introduction: The plant Barleria prionitis (family: Acanthaceae) is a traditional herb it is widely distributed in India and it has important medicinal value. The aim of present research work was to evaluate the anti-parkinsonrole of aqueous extract of Barleria prionitis (AEBP). Methods: The anti-parkinson activity of AEBP was evaluated using MPTP induced Parkinson mice and Rotenone induced Parkinson rat models. Levodopa was served as reference standard for both animal models. Results: Extracts treated groups showed higher in vivo antioxidant and antiparkinson activities. They also showed higher activity in neurotransmitters level. AEBP exhibited similar anti-parkinson activity that of standard but with lesser magnitude. Conclusion: The result may be attributed to the chemical constituents namely iridoid glycosides existing in it which may be because of their specific or increasing effect that enhanced anti-parkinson activity and provided scientific evidence of the ethnomedicinal futures of Barleria prionitis. These findings could justify the inclusion of this plant in the management of parkinson’s disease. Keywords: Levodopa; In vivo; Neurotransmitters; Ethnomedicine, Dopamine, GABA
Publication date: 01/09/2020

https://ijbpas.com/pdf/2020/September/MS_IJBPAS_2020_5144.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.9.5144