The aim of the present research work was to develop and evaluate colon specific sustained
release matrix tablet of Mesalamine using different concentrations of microbial-dissolvable
polysaccharide Locust Beans Gum. The drug polymer compatibility studies were determined
by using FTIR & DSC.Matrix Tablets of Mesalamine were prepared by wet granulation
method & evaluated for Pre, Post compression parameters like tapped density, bulk density,
Hauser’s ratio, compressibility index, and compressibility index was studied.The hardness,
friability, weight variation, drug content etc. Dissolution studies were performed in HCl
buffer pH1.2, Phosphate buffer pH 7.4 and Phosphate buffer pH 6.8 Cecal content in order to
mimic the conditions from mouth to colon. The FTIR spectra of pure Mesalamine and in the
formulation were found to be identical. FTIR & DSC drug, polymer7 in Physical mixture
shows no interaction between the drug and polymer. Preformulation study suggests powders
blends shows acceptable flow properties. Developed colon targeted tablets possessed the
required physicochemical parameters such as hardness, friability, weight variation, drug
content. Formulated with Locust bean gum, F1&F2 only 6.4±0.15 and 5.21±0.52 % drug release was observed in the upper part of the GIT. F1 batch showed better drug release, that
is, 95.1±1.25%, at the end of the 12 hour of dissolution study in the presence of rat Cecal
Contents, in comparison to batch F-2, which released 81.4±0.18%. The results of the present
study have demonstrated that developed colon targeted tablet were promising vehicle for
preventing rapid hydrolysis in gastric environment. Finally, the studies confirmed that
microbial triggered locust bean gum based colon targeted matrix tablet of Mesalamine is a
potential system to target the drug release in the colon for better treatment of ulcerative
colitis.
Keyword: Mesalamine, Locust Beans Gum, Colon, Matrix, Tablet
Publication date: 01/08/2020
https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5169.pdf
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https://doi.org/10.31032/IJBPAS/2020/9.8.5169
