ABSTRACT

Hydrilla verticillata (HYD) is well reported to modify inflammatory response and oxidative stress which are key pathophysiological finding of cerebral reperfusion injury. Therefore present work was designed to investigate the effect of HYD on cerebral reperfusion injury in rats. Each protocol comprised cerebral ischemia (CI) for 30 min followed by reperfusion(R) for 1 h. Animals were treated with HYD (50mg/kgp.o) for seven days. At the end of the experiment, brain tissue was utilized for the measurement of oxidative stress markers, inflammatory response, infarct size and histopathological findings. HYD treated rats demonstrated a significant reduction in infarct sizes when compared with CI/R group of rats. HYD treatment demonstrated a significant decreased in malondialdehyde, nitric oxide levels and a significant increase inthe level of reduced glutathione, superoxide dismutase and catalase,showed modification in oxidative stress. HYD treatment confirmed a significant decrease in myeloperoxidase, C - reactive protein and TNF-? levels indicated a change in the inflammatory response. Histopathological findings revealed a reversal of damage in HYD treated rats. HYD treatment reduced DNA fragmentation of brain tissuein treated animals. HYD was found to be cerebroprotective against CI/R by anti-inflammatory and antioxidant activities. Keywords: Cerebral Reperfusion Injury, Hydrilla verticillata, Stroke
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5162.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.8.5162