ABSTRACT

The present study was carried out to evaluate the antistress potential of apricot kernel extract (AKE) in albino mice using different experimental models such as swimming endurance (SET), tail suspension (TST), writhing test (WT) and anoxia stress tolerance (AST). Acute toxicity studies were performed on Wistar rats to select doses of AKE. Diazepam (2 mg/kg i.p.) was taken as a reference drug for comparison. In SET, AKE-treated mice showed a significant (P<0.01) decrease in immobility time (46.32 ± 1.086 s and 40.09 ± 1.25 s respectively) at a dose of 100 and 200 mg/kg as compared to the control and standard group. While a significant (P<0.05, P<0.01 respectively) increase in anoxic tolerance time (32.06 ± 0.42 s and 45.10 ± 1.37 s respectively) was observed in AST at the same doses. In WT, the effect of glacial acetic acid was reduced by AKE at both the doses (100 and 200 mg/kg) as indicated by a decrease (P<0.01) in the number of writhes (37.33 ± 0.95, 30.16 ± 1.27 respectively) as compared to control and standard group. In TST, the AKE-treated mice produced a significant (P<0.01) decrease in the duration of immobility (34.25 ± 1.10 s and 24.08 ± 1.55 s respectively) in comparison to the control and standard group at both the doses. It was observed that AKE possessed a significant antistress activity at both the doses in all tested models although the results were more prominent at higher dose (200 mg/kg). Keywords: Immobility, Phytochemical screening, Antistress activity, Acute toxicity studies, Prunus armeniaca L. (Apricot)
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5161.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.8.5161