ABSTRACT

Acorus calamus has been used as a medicinal plant in Asia from the last 2000 years. To investigate the anti-cancer activity of rhizome of A.calamus, the methanolic extracts of the rhizome were prepared. In this study anticancer effect of A. calamus was evaluated on breast cancer (MCF-7) cell line and ELF-5 by in vitro and Insilco method. The MTT assay were used to determine cytotoxicity against breast cancer cell line.MCF-7 cells were cultured in DMEM medium and incubated with different concentrations of A.calamus extract. The cell viability was assessed by MTT assay. A.calamus has decreased effect on malignant cells in a concentration dependent manner. Among the different concentration tested the higher concentration had a considerable effect for the inhibition of cancer cells. In case of insilico studies acitretin is a potent phytochemical of Acorus calamus that can effectively inhibit the target protein ELF-5. Keywords: Acorus calamus, MCF-7, ELF-5, breast cancer
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5160.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2020/9.8.5160