ABSTRACT

Introduction: Plants represent untapped reservoir of novel compounds, hence dominate indigenous system of medicine. Exploration of herbal drug is directly related to its traditional utilization in alternative medicine. Dermatophytosis/ ringworm is caused by keratinophilic fungi and is a common skin problem in country like India where climatic conditions favors the infection. Selected plant Abrus precatorius is being used to treat various skin infections in folklore medicine. In the present study efforts are made to identify new sources with antidermatophytic potential from selected plant. Material and methods: Shade dried parts of the plant were subjected to flavonoid extraction by following well-established protocols and tested against test dermatophytes to screen their antidermatophytic nature. Minimum inhibitory concentration and minimum fungicidal concentration (MIC and MFC) was also determined along with total activity (TA). Results: Remarkable inhibition zone (IZ) and activity index along with low values of MIC and MFC were recorded for the active extracts. Same values of MIC and MFC were found for most of the extracts which indicated their fungicidal nature. Trichophyton mentagrophytes, T. rubrum and E. floccosum were observed more susceptible than M. canis and M. gypseum. Free and bound flavonoids were recorded to be highly antidermatophytic against all test pathogens. Greater values of total activity of flavonoid extracts also indicated their potent antidermatophytic nature. Conclusion: Present study recommends chemical exploration of flavonoid extracts of stem and leaves and preclinical evaluation of the same. Potential antidermtophytic compounds may be used as a topical ointment and/ or hand sanitizer/ wash. Keywords: Abrus precatorius, flavonoids, dermatophytosis/tinea/ringworm, dermatophytes
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5159.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.8.5159