ABSTRACT

The purpose of this study was to investigate the diabetic effect of phytocompounds of Lepisanthes tetraphylla (Vahl) Radlk through in silico molecular modelling studies. Molecular docking was carried out against human pancreatic alpha-amylase, human dipeptidyl peptidase IV, human PPAR-gamma and Glucagon receptor using Glide module. ADMET properties were calculated using quikprop module. Phytocompounds showed better binding score against human PPAR-gamma protein. Compound Lucenin was identified as a potent lead molecule in the management of diabetes mellitus. Keywords: In silico docking, Diabetes Mellitus, Lepisanthes tetraphylla (Vahl) Radlk, ADMET
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5158.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.8.5158