ABSTRACT

Background: Gold nanoparticles (AuNPs) act as efficient carriers for drug delivery applications. Because they allow controlled intracellular release. AuNPs are preferred because of their high biocompatibility, and ease of synthesis. Present work reveals the capability of green synthesis of gold nanoparticles by the leaves of pharmacologically important plant Plectranthus amboinicus. Cervical Cancer is one among the commonly occurring diseases in women.A potential drug with anticancer property was the need of the hour. Aim: To synthesize and characterize gold nanoparticles from Plectranthus amboinicus and study its ability to inhibit cervical cancer using cell line HeLa. Materials and Methods: Synthesis was done using aqueous method since it was rapid and cost effective. The synthesized gold nanoparticles were characterized by using UV–vis spectroscopy, FTIR, SEM analysis. Results: The results of SEM showed that the nanoparticles are in spherical shape. FTIR confirmed the presence of characteristic peaks of gold nanoparticle. Conclusion: Thus, the synthesized gold nanoparticles were tested for their anticancer potential for cervical cancer cell line HeLa and the result was determined to be positive using MTT assay and AO/EB staining. Keywords: Gold Nanoparticles, Green synthesis, HeLa, Plectranthus amboinicus
Publication date: 01/08/2020

https://ijbpas.com/pdf/2020/August/MS_IJBPAS_2020_5152.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.8.5152