ABSTRACT

Hyperlipidemia is a metabolic sickness considered by increased concentration of any class of plasma lipids e.g. cholesterol, triglycerides, cholesterol esters or phospholipids. Epidemiological facts have shown that hyperlipidemia is accountable for 4.4 million expiries every year. Statins have been frequently used as anti hyperlipidemic drugs for primary and secondary stages but some natural cures like Moringa Oleifera have also been used for treatment of hyperlipidemia. The existing study was directed to link the anti hyperlipidemic effects of Simvastatin and M.oleifera in hyperlipidemic patients. It was a cross sectional study in which 30mild to moderate hyperlipidemic male patients in three sets with average age of 35 to 45 years were included. Group I was given placebo (corn starch capsule) while groups II and III were treated with simvastatin (20mg OD) and M. oleifera leaf powder capsule (500mg bd) respectively. Blood samples were collected at zero, 15, 30, 45, 60, 75, 90 days. Cholesterol, LDL, HDL and Triglycerides were observed. Statistical analysis was performed using one-way analysis of variance (ANOVA). Results have shown that M.oleifera had significantly decreased the value of Cholesterol, LDL and Triglyceride level with a potential result on triglycerides with a value of (P ? 0.01), while there was non-significant difference on HDL by M.oleifera. However, Simvastatin have significantly decreased the level of cholesterol. Study concluded that M. oleifera is a better, indigenous and safer therapeutic option. It may suggest to improve the quality of life. Keywords: Hyperlipidemia, Simvastatin, Moringa Olifera, Cholesterol, HDL, LDL
Publication date: 01/06/2019

https://ijbpas.com/pdf/2019/June/MS_IJBPAS_2019_47391.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.6.4739