ABSTRACT

Background: Prostate cancer is cancer of the prostate gland. The prostate gland is located below the bladder and in front of the rectum. Finasteride (FNS) is one of the drugs of choice for the treatment of prostate cancer. But the conventional dosage form of this drug has low bioavailability so that, this research is designed to enhance the bioavailability of FSN using microemulsion. Aim and Objectives: Aim of the study is to formulation development and characterization of microemulsion system. The objectives of this research are formulation of the FNS microemulsion, characterization of FSN microemulsion and evaluation in vitro drug release study. Methods: FSN Microemulsion was prepared by water titration method using different concentrations of surfactant mix (1:1, 2:1, 3:1 and 4:1) and formulated Microemulsion was characterized for its drug content Droplet size analysis and Polydispersity Index Zeta potential Surface morphological analysis, pH measurements, Dye-solubility test, In vitro drug release and Ex vivo drug release. Results: Particle size of the formulation was found to be between 722.5 to 3814 nm, Poly dispersity Index and Zeta potential shows between 0.692 to 1and -2.42 to -11.6 respectively. Based on the dye-solubility study 1:1 ratio formulation was selected as the best formulation. The TEM result shows spherical shape of FSN microemulsion. Conclusion: Results of this study concluded that, Surfactant (mix) ratio Tween 80: PEG 400 (F1) is the suitable surfactant ratio for the formulation of FNS microemulsion. Keywords: Microemulsion, PEG 400, Tween 80, Zeta potential, Ex vivo release
Publication date: 01/07/2020

https://ijbpas.com/pdf/2020/July/MS_IJBPAS_2020_5104.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.7.5104