ABSTRACT

This study evaluated the antioxidant activity and angiotensin converting enzyme (ACE) inhibitory activities of seed extracts of Garcinia cambogia. Among the three extracts tested, methanol extract has shown significant DPPH radical scavenging activity with IC50 value of 15.99 ?g mL-1, total antioxidant activity (TAA) of 19.7 ?g mL-1 and ferric reducing potential of 130.2 ?g mL-1. Further, methanol extract has shown potential ACE inhibitory activity with IC50 value of 198.82 ?g mL-1. Gas chromatography-Mass spectrometry analysis was carried out to locate the possible active principles responsible for the ACE inhibition and antioxidant activity. GC-MS analysis revealed the presence of various phytochemicals such as phenolics, flavanoids, tannins and terpenoids. Results of in vitro studies of antioxidant and ACE-inhibitory activities suggest that G. cambogia seeds have strong antioxidant and ACEinhibitory properties. Further, isolation and characterization of ACE-inhibitory molecules will be of greater importance. Keywords: G. cambogia, Angiotensin converting enzyme, Antioxidant, Hypertension, GC-MS
Publication date: 01/07/2020

https://ijbpas.com/pdf/2020/July/MS_IJBPAS_2020_5097.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.7.5097