ABSTRACT

The present work aims to synthesize biocompatible Copper (II) Oxide (CuO) nanoparticle using the extract of the medicinal plant Cyathea nilgiriensis Holttum. The synthesized Nanoparticle is characterized by FTIR, XRD, PSA, SEM and EDX studies. FTIR studies confirm the presence of biomolecules and metal oxide in the prepared nanoparticle. X-ray diffraction (XRD) structural analysis reveals the formation of pure hexagonal phase structures of CuO nanoparticles. Particle size analyzer (PSA) studies have proved that the biosynthesized CuO nanoparticle is below 100 nm in size. The surface morphology of CuO nanoparticles observed through Scanning electron microscope (SEM) suggests that most of the CuO crystallites are flower -shaped. Energy Dispersive X-Ray (EDX) analysis confirms the presence of both copper and oxygen. The possible mechanistic schemes of copper oxide nanoparticles are also predicted. The biosynthesized copper oxide nanoparticles exhibit strong antimicrobial behavior against gram positive and gram negative bacterial species and fungal species. The anticancer activity against Daltons lymphoma ascites (DLA) cells hasbeen studied for the green-synthesized CuO nanoparticles. The anticancer activities exhibit good behavior against DLA cell lines. Keywords: Cyathea nilgiriensis Holttum, CuO nanoparticles, green chemistry, Characterization, antimicrobial & anticancer activity
Publication date: 01/06/2020

https://ijbpas.com/pdf/2020/June/MS_IJBPAS_2020_5188.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.6.5188