ABSTRACT

Tuberculosis is a pretty dangerous disease if not pick up accurately, triggered by a gram negative rod Mycobacterium tuberculosis. First line anti tuberculosis drugs, considered as top therapeutic approach to eradicate the infectious organism, which are also responsible for causing severe hepatotoxic effects. Silymarin is used since decades to compensate the noxious effects instigated by first line anti tuberculosis drugs. In this study Thymoquinone used as hepatoprotective agent in rabbit models. Our study suggests that thymoquinone appear to produce more reliable hepatoprotective effect as compare to silymarin. Results are supported by histopathological studies and Biochemical analysis. Thymoquinone in concentration of 40mg/kg showed mean value 17.08*** for ALT and 50.376* for AST which is quite better as compare to silymarin. Keywords: Tuberculosis, Mycobacterium tuberculosis, Thymoquinone, Silymarin, AST, ALT
Publication date: 01/06/2020

https://ijbpas.com/pdf/2020/June/MS_IJBPAS_2020_5147.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.6.5147