ABSTRACT

Hashimoto disease is one of the most frequently occurring autoimmune diseases, characterized by lymphocytic infiltration, destruction and scarring of thyroid tissue. It is reported several factors related on its pathogenesis. Among environmental factors smoking and alcohol have significant effects, both protective as well as for aggravating the disease, even though the precise nature of these effects are not clearly known. There are elevated levels of circulating antibodies against the thyroid proteins, mainly thyroid oxidase, thyroglobulin and thyroid stimulating hormone receptor, in patients with HT. Linkage and association studies in AITD identified several major genes that are relevant for the onset of AITD, including the thyroid-specific genes, thyroglobulin and thyroid-stimulating hormone receptor and also many immune-regulatory genes. Keywords: Hashimoto’s hypothyroidism, Autoimmune thyroid disease, environmental, Genetic factor
Publication date: 01/06/2020

https://ijbpas.com/pdf/2020/June/MS_IJBPAS_2020_5064.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.6.5064