ABSTRACT

Carissa carandas (Apocynaceae) a perennial, flowering shrub was evaluated for its neuroprotective effects in various animal models i.e Open Field Activity, Rearing Test, Head Dip Test. CNS Depressant Activity, Traction Test and Cage Crossing Movement. Administration of etahnolic fruit extract extracts of Carissa carandas, showed an increase in exploratory functions as compared to the control group in a dose dependant manner. Etahnolic fruit extract extracts of Carissa carandas significantly (p < 0.01) increase in head-dipping behavior of the animals in Head-dipping tests. A significant (p<0.01) dose-dependent antidepressant effect was observed in cage cross activity. A mild dose-dependent muscle-relaxant activity was also observed. Phytochemical screening of C. carandas revealed the presence of alkaloids, glycosides, steroids, saponins, tannins, proteins, phenolic compounds and flavonoids. A number of researcher reported that the alkaloids, glycosides, and flavonoids rich plant extracts possess sedative, anxiolytic, and antiepileptic properties mediated through their affinity with benzodiazepine site of GABAergic complex system in the brain producing drowsiness and facilitating or maintaining sleep. The results obtained in this study suggest that the C. carandas possesses anxiolytic and muscle relaxant properties. Thus, C. carandas has potential clinical applications in the management of anxiety and muscle tension disorders. Further investigations are warranted for elucidating the exact mechanism and bioactive compounds. Keywords: Carissa carandas, anxiety, neuroprotective, depression
Publication date: 01/06/2020

https://ijbpas.com/pdf/2020/June/MS_IJBPAS_2020_5035.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.6.5035