ABSTRACT

The novel Schiff base has been designed and its metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from their relating metal chlorides utilizing the bioactive ligand acquired from Indole-2,3-dione and 2-(2-aminophenyl)benzimidazole in alcoholic media. Several tools like elemental analyses, magnetic susceptibility, molar conductance, FT-IR, Far IR, UV-Vis, 1H NMR, Cyclic voltammetry and ESR have been used to obtain the chemical structures of synthesized transition metal complexes. Spectral studies showed that the Schiff base was behaved as Nitrogen and oxygen coordinating chelating agents. Electronic spectra coupled with magnetic susceptibility data suggested that all complexes possess an octahedral geometry. The in vitro biological screening impacts of the explored compounds were tested against the bacterial species (Bacillus subtilis, Salmonella typhi) and fungal strains (Aspergillus niger, Candida albicans) by disc diffusion method. A comparative study of inhibition values of the Schiff base ligand and their complexes indicate that the Co-complexes exhibit higher antimicrobial activity than other complexes. The compounds synthesized were screened for anticonvulsant potentialities in Albino Wistar Rats by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test respectively. The toxicity and hematological properties were inspected for prepared compounds by subacute toxicity study. The results revealed that compounds were found to exhibit significant anticonvulsant property at 10 mg/kg dose level when compared with the reference drug phenytoin in both seizure tests. Keywords: Schiff base, Isatin, 2-(2-aminophenyl)benzimidazole, Antimicrobial, acute toxicity and Anticonvulsant activity
Publication date: 01/05/2020

https://ijbpas.com/pdf/2020/May/MS_IJBPAS_2020_5066.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.5.5066