ABSTRACT

This research work aimed at synthesis of some new cobalt coordination compounds using ligands of acetohydrazone Schiff bases with quinoline core in their structure. Four derivatives of acetohydrazone ligands were synthesized using 2-(quinolin-8-yloxy) acetohydrazide and condensed with different aromatic aldehydes. These ligands were used further in preparing mononuclear Co(II) complexes. The synthesized compounds structures were elucidated by different analytical methods. Their potential antimicrobial activities were assessed in vitro against different bacterial and fungal strains. Co(II) coordination compounds showed little enhancement in the activity against the gram-positive bacterial strains compared to their parent organic ligands. The compound [Co(HL3)2] was the most active chemical against both grampositive S. aureus and E. faecalis bacteria. Keywords: Acetohydrazone, Quinoline moiety, Co(II) coordination compounds, Antimicrobial activity
Publication date: 01/05/2020

https://ijbpas.com/pdf/2020/May/MS_IJBPAS_2020_5051.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2020/9.5.5051