ABSTRACT

Sapindus mukorossi Linn belongs to the family Sapindaceae. The fruit is valued for the saponins (10.1%) present in the pericarp and constitutes up to 56.5% of the drupe known for inhibiting tumour cell growth and traditionally fruit of Sapindus mukorossi is used for epilepsy, chlorosis (Iron deficiency anaemia) and excessive salivation. In the present study an attempt was made to isolate saponins from Sapindus mukorossi and to evaluate the cardioprotective potential of isolated saponins against isoproterenol induced cardio toxicity in wistar rats. The pericarp of Sapindus mukorossi is powdered, extracted with water and was subjected for phytochemical screening. The saponins (200mg/kg) exhibited significant cardio protective effect against Isoproterenol (2 mg/Kg, i.p.) induced myocardial damage by showing the reduction in cardiac biomarkers like CK, CK-MB, and troponin (I). It is also evidenced by histopathological studies isoproterenol exhibited pathological changes in cardiac muscle including several congestions, subendocardial necrosis and abundant hyperplasia along with increased edematous intramuscular space while administration of the isolated saponins (200 mg/Kg) exhibited normal appearance with mild changes in congestions and necrosis as like with standard drug propranolol (10 mg/Kg). This research proved that the presence of saponins in Sapindus mukorossi fruits can protect the heart from the myocardial infarction condition. Keywords: Sapindus mukorossi, saponins, cardiotoxicity, cardioprotective, biomarkers, Sub-endocardial necrosis
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_5020.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.5020