ABSTRACT

The main aim of this investigation is to investigate the cardioprotective effect of ethanolic extract of Ipomoea biloba on isoproterenol induced myocardial infarction in rats. The rats were divided into five groups of six animals each. Group I served as a normal control, Group II rats were administered isoproterenol (20mg/kg) through sub cutaneous injection to induce the myocardial infarction. Group III and IV were pretreated with ethanolic extract of Ipomoea biloba leaf (100mg/kg, 200mg/kg respectively) before to the subcutaneous injection of isoproterenol (20mg/kg, b.w) for 2 consecutive days. Group V received ethanolic extract of Ipomoea biloba (200mg/kg b.w) alone for 28 days excluding the treatment procedures. After the completion of experimental period, the levels of cholesterol, triglycerides, phospholipids, and lipoproteins were estimated. The myocardial damage was assessed by quantifying the serum levels of cardiac marker enzymes (AST, ALT, LDH, CK, and TP) uric acid, and ceruloplasmin. The results of this experiment revealed that the Isoproterenol induced rats showed a significant increase in the levels of triglycerides, total cholesterol and phospholipids in both serum and heart homogenate. A rise in the levels of LDL, VLDL with significant decrease in the level of HDL was also observed in the serum of isoproterenol-intoxicated rats. Interestingly our findings were proved that the treatment with ethanolic extract of I.biloba leaf was showed the noticeable decrease in the lipid profiles and myocardial marker enzymes in the experimental rats. The extract treatment also prevented the elevation of cholesterol, triglycerides and phospholipids in myocardial infarction induced rats. Hence, the findings of this work was clearly proved that the I.biloba leaf was appreciably prevented the isoproterenol induced myocardial infarction in rats. Keywords: Cardiopreotective activity, isoproterenol, myocardial infarction, Ipomoea biloba
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_5016.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.5016