ABSTRACT

With the findings of bioactivity of isatin derivatives, present investigation aim to synthesize new isatin derivatives (PD1-15) and evaluation for their antimicrobial activity. The isatin derivatives were obtained by reaction of istain (1) with p-phenylenediamine (2) in ethanol to afford 3-(4-aminophenylimino)-indolin-2-one (3) on chloroacetylation to afford the N-(4-(2- oxoindolin-3-ylideneamino)-phenyl)-2-chloroacetamide (4) which further reacted with different phenols and primary amines in presence of anhydrous potassium carbonate in acetonitrile. The test compounds characterized by spectroscopic methods. All the test compounds were screened for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Escherichia coli, Klebsiella pneumoniae (Gramnegative bacteria) and Candida albicans, Aspergillus niger, Penicillium chrysogenum, Rhizopus oryzae (fungal strains) by cup-plate method by measuring zone of inhibition. The MIC value of potent test compounds was also determined. Molecular properties of test compounds were determined by online software. The results showed isatin derivatives may be optimized as lead compound as antimicrobials. Keywords: Isatin; Antimicrobials; Molecular properties, Phenols, Amines
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_5006.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.5006