ABSTRACT

Transdermal drug delivery (TDD) has advantages over oral drug delivery. However, the use of TDD is limited by the outermost layer of stratum corneum (SC) which exhibits low permeability. Recently, low frequency ultrasound mediated drug delivery has been studied as a method to enhance transdermal drug penetration. Several studies investigated the mechanisms of transdermal drug penetration with the help of ultrasound. In addition, cavitation is believed to be the predominant mechanism. Moreover, other studies discussed different ultrasound parameters and their effect on drug penetration through the skin. Several applications of TDD using ultrasound were approved on proteins, antibiotics, NSAIDs and other drugs loaded in nano carriers. This review presents the details of studies on ultrasound including ultrasound parameters and their effect on TDD, mechanisms of drug penetration due to ultrasound and various therapeutic applications using ultrasound. Keywords: ultrasound, low frequency ultrasound, transdermal drug delivery (TDD), cavitation
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_5001.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.5001