ABSTRACT

It is secret that living beings, including plants, livestock, fungi and cyanobacteria, undergoes a biological and inner process called circadian rhythm that controls the sleep-wake period and repeats about every 24 hours. This cycle is coordinated by the suprachiasmatic nucleus and controls about all body features, including related to drug delivery systems. The major aim is it should match with the circadian clock of the body indicating that these drug delivery systems deliver the right dose at a specific time at a particular site in order to accomplish this different techniques, such as time-controlled, pulsed, and programmed drug delivery systems which have been created and widely studied leading to chrono pharmaceutical drug delivery so that synchronization of this drug implementation with circadian rhythms leads to enhanced disease management and a higher patient therapeutic outcome. This review article tries to explain the function of circadian rhythms in different diseases and their states such as asthma, cardiovascular disease, arthritis, and cancer in a concise way. It also discusses the different oral drug delivery techniques introduced and their results in chronotherapeutic disease therapy. Keywords: Circadian rhythm, chronopharmaceutical drug delivery system, chronotherapeutic diseases, Pulsed drug delivery systems, Cardiovascular Diseases, Chronotherapy
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_5000.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.5000