ABSTRACT

Microspheres are the multiparticulate drug delivery systems which are manufactured to acquire prolonged or controlled drug delivery, which can enhance bioavailability, stability and also the drug can be delivered at a predetermined rate. Some of the difficulties of conventional therapy can be controlled by an effectively designed controlled drug delivery system and the therapeutic efficacy of a given drug is enhanced. Vast attention has been attained by this microspheric drug delivery system because of its prolonged release and also its wide range of application in drug targeting to the particular site in order to maximize the concentration of drug in a particular tissue or organ of the body that surpass the drug’s therapeutic efficacy, toxicity can be reduced and improves the patient compliance and patient comfort. Various approaches have been developed to deliver a drug to particular site in a sustained controlled release manner. Among them, one of the approaches is utilizing microspheres as drug carriers. Microspheres were used not only for prolonged release, but the anticancer drugs to the tumour also can be targeted. They consist of a drug which is centrally placed and a unique polymeric membrane that is biodegradable in nature is used to enclose it. The present review is anxious about the microspheres as novel drug delivery system. The main aim of the present study is to review various features of microspheres, methods used for preparation and various applications as targeted or controlled drug delivery system. Keywords: Microspheres, conventional, targeted, applications, controlled release
Publication date: 01/04/2020

https://ijbpas.com/pdf/2020/April/MS_IJBPAS_2020_4995.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.4.4995