ABSTRACT

Pteris vittata has traditionally been used for wound healing, abdominal pains, diarrhea but its hepato-protective and anti-inflammatory activities still cause of concern. Three extracts were prepared i.e., n-hexane, chloroform and methanol by using successive extraction. Hepatoprotective activity of these were checked in rats by carbon tetrachloride (CCl? 0.5 ml/kg) induced hepatic insult and Silymarin 200 mg/kg was used as standard drug. The biochemical and histopathological parameters were determined. In-vitro anti-inflammatory activity was done by using egg albumin denaturation method. The biochemical parameter confirmed that methanol extract of Pteris vittata lowers the alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and cholesterol levels in rats and has shown maximum hepatoprotective activity as compared to other extracts. The histopathological examination of liver tissues also indicated that the methanol extract of Pteris vittata exhibited the strongest hepatoprotective activity against CCl4 induced hepatotoxicity. In-vitro antiinflammatory activity showed that the value of IC50 confirmed that chloroform and n-hexane extract exhibited maximum anti-inflammatory activity when compared to standard drug (diclofenac sodium). It is concluded that Pteris vittata possesses hepatoprotective and anti-inflammatory activities which might be due to the presence of phytoconstituents which were confirmed by phytochemical investigation. Pteris vittata if used as natural remedy will help the mankind to recover from illness like liver diseases and inflammation without any significant adverse effect. Keywords: Pteris vittata, hepatoprotective, carbon tetrachloride, anti-inflammatory
Publication date: 01/03/2020

https://ijbpas.com/pdf/2020/March/MS_IJBPAS_2020_5015.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.3.5015