ABSTRACT

Four new Cu(II), Ni(II), Co(II) and Mn(II) metalloinsertors have been synthesized by using a Schiff base, formed by the condensation reaction of isatin, p-chloroaniline with 1, 10- phenanthroline. They have been structurally characterized by IR, UV–vis, NMR, EPR, elemental analyses, molar conductivity and magnetic susceptibility studies. The molar conductance data of the complexes indicate that they are non-electrolytes in nature. The spectral and analytical data reveal that the complexes take up distorted octahedral geometry. They have been examined for their antibacterial activities against few pathogens. The data reveal that the complexes exhibit better biocidal activities against bacteria than the free Schiff base ligand. The gel electrophoresis experiment reveals that the complexes are good chemical nucleases. Keywords: Metal complexes, Antibacterial activity and DNA cleavage
Publication date: 01/03/2020

https://ijbpas.com/pdf/2020/March/MS_IJBPAS_2020_4989.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.3.4989