ABSTRACT

Background: The diabetes mellitus is a severe multifaceted chronic disease that is distinguished by the hyperglycemia and annoyances of metabolisms and absolute or partial deficiency of the insulin. Presently, there are almost 150 million diabetes cases were accounted and this may relatively increase to nearly 300 million or even more by the year 2025. Objective: The current research work was aimed to examine the anti-diabetic potential of ethanol extract of Ipomoea staphylina against the Streptozotocin induced diabetes in experimental rats. Methodology: The diabetes was induced to the rats by injecting the 55mg/kg of streptozotocin by intra peritoneal route. The liver function marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) was estimated by using the standard methods. The total protein, urea content, creatinine, uric acid level, cholesterol, triglycerides, free fatty acids and the phospholipids were studied. The levels lipoproteins were also measured in the experimental animals. Results: The ethanol extract of Ipomoea staphylina leaves was showed the noticeable reduction in the ALT, AST and ALP in the serum of diabetic induced rats. The extract treatment also reduced the urea, uric acid and creatinine levels. The decreased levels of cholesterol, triglycerides, fatty acids and phospholipids were noted in the extract treatment. Conclusion: In conclusion, our overall findings from this research work were proved the antidiabetic potential of Ipomoea staphylina leaves against the Streptozotocin induced diabetes in experimental rats. These results were proved the anti-diabetic potential of Ipomoea staphylina and proposed that it may be useful for the development of novel anti-diabetic agents. Keywords: Diabetes, Ipomoea staphylina, liver enzymes, phospholipids, glucose and Glibenclamide
Publication date: 01/03/2020

https://ijbpas.com/pdf/2020/March/MS_IJBPAS_2020_4976.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.3.4976