ABSTRACT

Purpose:The purpose of this study was to develop optimize and characterize Quercetin loaded chitosan (CS) nanoparticles. Method:Chitosan nanoparticles of chitosan have been prepared using modified ionic gelation method. Box Behenken design with 15-runs was implemented. Polynomial equation, contour and 3D response surface plots were generated to relate the factors and responses. Prepared nanoparticles were characterized for particle size, Zeta potential, polydispersity index, entrapment efficiency, in-vitro release study along with FTIR, Differential scanning calorimetric and Scanning electron microscopy. Result: It was proved that there was no any interaction showed between drug and excipients.A formulation showed prolonged drug release of up to 8 hrs by 45-52 %, smaller particle size, and narrow particle size distribution with good entrapment efficiency. Conclusion:Processing parameters of chitosan nanoparticles were optimized by using box behenken design. Keywords: Chitosan, Box Behenken Design, Ionic gelation method, Quercetin
Publication date: 01/02/2020

https://ijbpas.com/pdf/2020/February/MS_IJBPAS_2020_4971.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.2.4971