ABSTRACT

Objectives: The objective of this study was to evaluate various lipid rich diets for the induction of dyslipidemia in animal model. Methods: This was an experimental study conducted on 42 Wistar albino rats. Animals were randomly divided into 7 groups on the basis of administration of various oils, including Canola oil, Coconut oil and Banaspati ghee alone and in combination of any two of them simultaneously; while one group served as control was administered normal saline. Baseline body weights of all groups of animals were measured at the start of the study. At the end of 4 weeks of lipid diets, body weight of all groups of animal groups was measured again and their blood was drawn through cardiac puncture for the assessment of TC, LDL-C, HDL, TGs. Results: Amongst all the groups, Group F (Banaspati ghee + Coconut oil) showed maximum increase in LDL-C, TC,TGs, body weight and decrease in HDL-C (p-value <0.05) in comparison to control. Conclusion: It is concluded that the combination of Banaspati ghee and Coconut oil may prove to be most effective lipid diet for the induction of dyslipidemia in animal model. ABBREVIATIONS: TC- Total Cholesterol; LDL-C – Low Density Lipoprotein Cholesterol; HDL-C – High Density Lipoprotein Cholesterol TGs- Triglycerides Keywords: Animal study, induction of dyslipidemia, wistar albino rats, lipid rich diet
Publication date: 01/02/2020

https://ijbpas.com/pdf/2020/February/MS_IJBPAS_2020_4967.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.2.4967