ABSTRACT

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in grampositive and gram-negative bacterial infections. It is a bactericidal antibiotic. Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis. In the present study an attempt has been made to enhance the dissolution rate of a poorly water soluble drug Cefadroxil through the use of super disintegrants. Three super disintegrants, namely, croscarmellose sodium, crospovidone and sodium starch glycolate indifferent concentrations (2, 4, 6 and 8 percent) were employed. The drug selected for present work is Cefadroxil, drug which in the form of hard gelatine capsule. Cefadroxil showed maximum absorption at 278.0 nm and obeyed Beer’s law in concentration range of 10-80 ?g/ml. Results of analysis were validated statistically and by recovery studies. The proposed method is new, simple, eco-friendly, economic, and accurate and can be utilized in routine analysis of cefadroxil tablets. Keywords: Hydrotrophy, Spectrophotometry, Dissolution Studies, Croscarmellose Sodium and Cros-povidone as Dispersants
Publication date: 01/02/2020

https://ijbpas.com/pdf/2020/February/MS_IJBPAS_2020_4945.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.2.4945