ABSTRACT

Orodispersible tablets of Piroxicam Beta Cyclodextrin and Tizanidine HCl combination were formulated using superdisintegrants to impart fast disintegration. Eleven formulations were prepared based on different concentrations of two superdisintegrants cross carmelos sodium and kyron . Direct compression techniques were used to study the nature and concentrations of superdisintegrants on various features of these tablets. Pre-compression studies like bulk density, tapped density,angle of repose,compressibilityIndex, Hausner’s ratio and compatability studies such as Fourier transform infrared spectroscopy were perfomred. Various features such as Hardness, Thickness, Diameter, weight variation, Friability, Disintegration, Dissolution studies, Wetting time, and stability studies were evaluated. Out of these eleven formulations,F9 was considered to be a good formulation because it gave 95% release in 12 minutes. Keywords: Piroxicam BetaCyclodxtrin, Tizanidine HCl , Orodispersible Tablets
Publication date: 01/02/2020

https://ijbpas.com/pdf/2020/February/MS_IJBPAS_2020_4895.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.2.4895