ABSTRACT

Background: Tuberculosis (TB) has been one of the biggest health problems across the world in human history. Pakistan is at 5th amongst the 22 high TB burden countries in the world. Objectives of the current study were to assess the frequency of TB in different districts of KP and to investigate different risk factors and the association between different risk factors and TB in KP, Pakistan Material and Method: This study was conducted for a period of one year at Programmatic Management of Drug Resistant TB (PMDT) unit at tertiary care hospital, Lady Reading Hospital (LRH) Peshawar Pakistan. All the suspected cases were analyzed by LED-FM microscopy and Xpert MTB/RIF assay. The risk factors selected for investigation were demographic characteristics, socio economic, behavioral factors and clinical manifestations. Results: Out of 1691 suspected TB cases; MTB was detected in 1015 (60%) cases. Out of MTB, 137(13.5%) were drug resistant. Females with productive age (<44 years) were found infected more than males. Among diabetes, arthritis and hepatitis which were analyzed as comorbidities with TB diabetes was found to be present in 9.3% of the cases of TB, followed by arthritis and hepatitis which was present simultaneously with TB in 3% and 9% of the cases. The most obvious clinical manifestation of TB was found to be productive cough which was present in 92% of the cases. Weight loss was recorded in 62.5% cases, while hemoptysis was reported by 58.1% TB patients. Conclusion: The results of logistic regression showed that visit to high burden countries, age and active smoking were positively associated with the burden of this disease. Keywords: Tuberculosis, risk factors, Xpert MTB/RIF assay, Khyber Pakhtunkhwa
Publication date: 01/01/2020

https://ijbpas.com/pdf/2020/January/MS_IJBPAS_2019_4928.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.1.4928