ABSTRACT

The present work is to screen the selected phytochemicals for alleviate chemical induced acne in mice. The treatment for acne with synthetic drugs have various drawbacks, usage may lead to development of resistant towards these drugs. Hence plants derived compounds are required to overcome the above drawbacks and treat the acne. Present study was aimed to evaluate anti acne potential of selected phytochemicals on the primary clinical lesion, microcomedone, which are the precise, almost all other acne lesions by applying topically on skin. Animals of either sex were collected from the animal house of Chalapathi Institute of Pharmaceutical sciences were randomized into 10 groups consisting of five animals/ group. Benzalkonium chloride used for inducing acne. The test compounds (2% geraniol, 2% hesperidine 2% ellagic acid and 2%liquorice) showed that decreased the inflammation in mice ear. On the10th day there was a significant decrease (p<0.0001) in inflammation (0.66±0.1503, 0.32±0.0734, 0.32±0.0734) with respective to the disease control. The test compounds at 2% showed significant reduction in the overall damage caused by acne induced by chemical contact and reduced the proliferation of inflammatory cell into the ear region. Keywords: Acne, Benzalkonium chloride, Ellagic acid, Hesperidine, and Geraniol
Publication date: 01/01/2020

https://ijbpas.com/pdf/2020/January/MS_IJBPAS_2019_4896.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.1.4896