ABSTRACT

New 1,2,4-triazole and 1,2,3-triazole as bis heterocyclic were synthesized using click chemistry approach. The chemical structures of the new triazolo compounds were confirmed by spectroscopic (IR), 1H-NMR, 13C-NMR, mass spectrometry (MS) and elemental analysis techniques. The antibacterial and antifungal activities of the new compounds have been evaluated. Some gram positive and gram negative bacterial strains were sensitive against some tested compounds. The compounds 7, 10 and 20 were active against most of the tested bacterial strains. Compound 10 showed highest activity among the series of tested compounds than the standard drug amoxicillin against S.a: Staphylococcus aureus, S.e: Staphylococcus Epidermidis and P.m: Proteus Merabilis. Also, compound 11, 12 and 18 were active against all the tested gram positive bacterial strains whereas inactive towards the tested gram negative bacterial strains. The five compounds 7, 10, 12, 18 and 20 were active against the candida albicans. Keywords: 1,2,3-Triazole,1,2,4-Triazole, Bis-triazole, Aromatic azide and Biological evalution

https://ijbpas.com/pdf/2019/December/MS_IJBPAS_2019_4890.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.12.4890