ABSTRACT

Adenosine to Inosine conversion is one of the most common modifications found in RNA world, a process known as A-to-I RNA editing. Adenosine deaminase that acts on RNA (ADA) is the main enzyme responsible for this A-to-I RNA editing and essential for RNA maturation. We have studied the structure prediction of Adenosine deaminase enzyme from Mycobacterium tuberculosis (MtADA). The structure prediction was done using homology modeling methods. Mus musculus ADA with sequence similarity of 47.6% with MtADA were used as template for model generation. The predicted model was validated using online servers and tools. The structural architecture and domain organization of MtADA was analyzed using various rapid computational approaches. The active site of MtADA was predicted containing residues Met309

https://ijbpas.com/pdf/2019/December/MS_IJBPAS_2019_4884.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.12.4884