The current study aimed to investigate the protective role of folic acid against the harmful toxic effects in rats induced by long term treatment by augmentin. In the current experiment, twenty-four adult male albino rats (170-200 g) were divided into four groups. The 1st group was the control group, it received saline solution (1 ml/kg). The 2nd group received folic acid (70 ?g/kg). The 3rd group received
augmentin (31.83 mg/kg). The 4th group was given augmentin and folic acid simultaneously. All doses were given orally and once a day for three weeks. At the day 22, rats were decapitated, blood samples were collected for hematological examination, whereas others were centrifuged, and serum was obtained and preserved for further biochemical examinations. The results showed that augmentin induced significant decreases in the levels of hemoglobin, hematocrit, RBCs, platelets, WBCs and superoxide
dismutases (SOD), and significant increases in serum cholesterol, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides, total protein, albumin and malondialdehyde (MAD). Simultaneous administration of folic acid with augmentin caused partial or complete enhancement in the hematological parameters such as hematocrit, WBCs count and hemoglobin. Also, biochemical parameters were partially improved by the folic acid administration
such as SOD or completely improved such as MAD by rendering them to values close to the normal saline control groups. According to the present study, it was suggested that co-administration of folic acid with augmentin modulates some of the hematological and oxidative stress parameters induced by
augmentin.
Keywords: Augmentin, Folic acid, hematology, nephrotoxicity, hepatotoxicity, oxidative stress and, Albino rats
https://ijbpas.com/pdf/2019/November/MS_IJBPAS_2019_4846.pdf
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https://doi.org/10.31032/IJBPAS/2019/8.11.4846
