ABSTRACT

The distribution of immuno reactivity of cortical synaptophysin was examined in the cerebrum of adult rats treated with seed extract of Citrullus lanatus, Omega H3 and soybean oil. Twenty (20) adult wistar rats of average weights 150g were used. The rats were randomly divided into 5 groups of 4 rats per group. Group A served as control, groups B and C received 100mg/kg and 200mg/kg of Citrullus lanatus ethanolic seed extract respectively, while groups D and E received 300 mg/kg of Omega H3 and 5ml Soybean oil for two weeks respectively. Serum lipids were estimated biochemically and statistically analyzed, Result was presented asmean ± standard deviation, P< 0.05 was considered statistically significant. The cerebrum was dissected, fixed, processed and stained for synaptophysin. The result shows Soya bean oil significantly increased total serum cholesterol and serum Low Density Lipoprotein compared with the seed extracts of C. lanatus and omega H3. Ethanolic seed extract of C. lanatus, Omega H3 and Soya bean oil had no significant effect on serum triglyceride. The low dose of the seed extract and Soya bean oil significantly decreased High Density Lipoprotein. In conclusion, the seed extracts of C. lanatus shows dose dependant enhancement activity on cortical synaptophysin than the other dietary supplements used in the study. Keywords: Synaptophysin, Citrulluslanatus, Lipoproteins, Cholesterol, Omega H3, Soyabean

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https://doi.org/10.31032/IJBPAS/2019/8.10.4836