ABSTRACT

Globallyamong all the factors of death Hyperlipidemia is considered as the mostmomentous one. Therapeutically Statins has been used to control hyperlipidemic crises worldwide at primary and secondary levels. Statins inhibit 3-hydroxy-3methylglutaryl-CoA (HMG-CoA) reductase, anobligatory enzyme for de novo synthesis of cholesterol. Commonly reported unwanted effects of Statins are myopathy, hepatobiliary disorders; rhabdomyolysis, peripheral neuropathy and sexual dysfunctioning. Simvastatin is reported to reduce total testosterone level from 13.4 moll/l to 11.4moll/l and it was also seen that there is a reduced sex hormone binding globulins SHBG value from 35.3 nmol/l to 27.6nmol/l when compared with the subjects who were not treated with simvastatin. The underlying mechanism for reduced testosterone is poor cholesterol availability in lyding cells of testes which use cholesterol for testosterone synthesis. A medicinal plant Moringa oleifera (M.oleifera) is commonly known for its reported anti-oxidant, antiinflammatory, antihyperlipidemic and anti-hypertensive properties. Leaves of M.oleifera decrease plasma cholesterol without depleting the testosterone levels. In this comparative cross sectional study 30 male individuals having moderate hyperlipidemia (200-250mg/dl of total cholesterol level), were selected and divided into three groups (10 each) and given corn starch as placebo to 1st group (G1), 20 mg simvastatin daily to 2nd group (G2) and capsules of 500mg of ground M. oleifera leaf powder to 3rd group (G3), for 90 days. 5ml of blood from each member of every group was collected at 0, 15, 30, 45, 60, 75, 90th day. Total serum testosterone was measured by using commercially available testosterone (human) ELISA kit (Abnova- KA0236 Size 96 wells version 02). Analysis of variance ANOVA test were applied in which probability value of

https://ijbpas.com/pdf/2019/November/MS_IJBPAS_2019_4829.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2019/8.10.4829