IN VIVO AND IN VITRO EFFECT OF CELEBREX ON EHRLICH ASCITES CARCINOMA CELL LINE Authors: Doaa A. Elsayed
ABSTRACT
Evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit
prostaglandin (PG) synthesis can reduce the incidence of cancers via its antioxidant activity.
Celebrex (celecoxib), a cyclooxygenase-2 (COX-2) inhibitor, is a NSAID with known antioxidant
and antineoplastic activity. The present study has been carried out to investigate the
chemopreventive effects of Celebrex on tumor development incidence and cytotoxicity on Ehrlich
ascites carcinoma cell line and bearing mice. Celebrex was given orally in a dose 30 mg/kg.
Antioxidant parameters were studied in blood samples and liver tissue, whereas immune
evaluations were performed in spleen tissue samples. Results show the ameliorative effect of
Celebrex on antioxidants status and immunity system of the treated mice.
Keywords: Celebrex, In vivo, In vitro, Tumor, Cytotoxicity, Ehrlich ascites, Immune System
