ABSTRACT

Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial tissues and glands which are located outside the uterus such as ovaries and peritoneal cavity. Females suffering from endometriosis often present with infertility. Aim of current study was to assess the thyroid profile in infertile women suffering from endometriosis. Current study was carried out in 50 females with clinically diagnosed endometriosis and 50 controls. Serum level of thyroid peroxidase antibodies (IU/Ml), Serum thyroxin (?g/dl), serum triiodothyronine (?g/dl), thyroid stimulating hormone (?g/dl), progesterone (ng/ml) and estradiol (pg/ml) was evaluated by commercially available human ELISA kit. Thyroid profile demonstrates their vibrant effect among disease group and normal individuals. Higher levels of TPO and T4 (61.65±7.19 IU/MI and 18.65±2.19 ?g/dl) were recorded in patients with endometriosis than that of controls (27.29±4.52 IU/MI and 8.31±1.56 ?g/dl) whereas the level of T3 (?g/dl) and TSH (?g/dl) was decreased significantly (p=0.032 and p=0.000). Current study concludes that thyroid profile may stimulate the progression and development of endometriosis. Proper control of thyroid profile may help to prevent endometriosis. Keyword: Endometriosis, ELISA, thyroid, endometrial tissues, endometriosis

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https://doi.org/10.31032/IJBPAS/2019/8.8.4795