ABSTRACT

Oral squamous cell carcinoma (OSCC) is a modern day catastrophe affecting millions of people around the globe, including Pakistan. It has gained worldwide attention owing to low survival rates, late detection, poor prognosis, and escalated mortality rates. Oral cancer affects men more than women as the former are more habitual users of notorious tobacco and tobacco products. Currently, the search for predictive OSCC biomarkers is in demand to maximize survival rates. The present study was done to evaluate the oxidative damage caused by increased lipidperoxidation in oral cancer subjects. Present research work provides strong evidence that oral cancer patients presented elevated peroxidation of lipids, and their products, enhanced formation of free radicals and reduced antioxidant enzymes in their serum, saliva and urine as compared to their healthy counterparts. Therefore the study strongly approves that lipoxidative biomarkers hold promise for their predictive potential in OSCC. Fifty subjects with diagnosed oral cancer through biopsy and pathological experiments were included in this study and fifty normal healthy individuals were taken as control. Results of current study shows that there were significantly (p=0.021) elevated levels of MDA were observed in patients of OSCC in their serum, saliva and urine as compared to healthy controls. Levels of isoprostane were also raised in patients among their serum saliva and urine (6.26±0.526, 1.66±0.019 and 1.26±0.426 pg/ml respectively) as compared to healthy controls (1.66±0.015, 0.616±0.017 and 0.166±0.019 pg/ml respectively), whereas the levels of 8-OHdG and 4-HNE were raised significantly (p=0.022 and p=0.019)) in serum, saliva and urine of OSCC patients as compared to healthy controls respectively). Keyword: Oral squamous cell carcinoma (OSCC), Malondialdehyde (MDA), 8-hydroxy-2- deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE)

https://ijbpas.com/pdf/2019/August/MS_IJBPAS_2019_4794.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.8.4794