ABSTRACT

The aim of our research study was to determine and compare the Quality Control of all brands of metformin HCl with the innovator brand available in the market of Pakistan at the city of Quetta Balochistan. Metformin HCl is mostly used in the treatment of type 2 diabetes in the result of debilitated insulin discharge. Metformin, is an oral biguanide, enhances hyperglycemia to improve peripheral sensitivity toward insulin and reduces gastrointestinal glucose breakdown and hepatic glucose formation. Five different brands were selected Glucophage, Neophage, Metphage, Neodipar, and Meteor. The Physiochemical properties of all brands were checked accordingly which includes Weight variation, Hardness, Thickness, Friability, Disintegration, Dissolution and Assay and compared with each other. The results of all these physiochemical properties showed that all the brands were within the acceptable range which followed the specifications of BP and USP. It is recommended that this type of research will be conducted in different formulations to check their physiochemical activities for the Quality of Product. Keywords: Metformin HCl, Glucophage, Neophage, Metphage, Neodipar, and Meteor

https://ijbpas.com/pdf/2019/August/MS_IJBPAS_2019_4778.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.8.4778