ABSTRACT

Rheumatoid arthritis (RA) is a chronic autoimmune disorder of unknown etiology. Studies indicate that RA is related to the oxidative damage caused by reactive oxygen species, but results have been inconsistent. The aim of this study is to measure the oxidant levels (xanthine oxidase and malondialdehyde) and antioxidant levels (enzymatic superoxide dismutase, catalase and nonenzymatic vitamin E) in the serum and synovial fluid of RA patients. Serum and synovial fluid samples from 146 patients (68 males and 78 females) with active RA and serum samples from 136 healthy volunteers (65 males and 71 females) set as control were collected. The level of oxidants and antioxidants were measured. RA patients had significantly higher mean serum xanthine oxidase and malonaldehyde levels, while levels of superoxide dismutase, catalase and vitamin E were significantly lower when compared to control. Female RA patients had significantly higher serum and synovial fluid xanthine oxidase and malonaldehyde levels when compared to their male counterparts but significantly lower serum and synovial fluid SOD levels. Moreover, the serum catalase levels were lower whereas the serum vitamin E levels were higher in female RA patients when compared to male, but differences were not significant. There was also a significant decrease in the synovial fluid catalase levels in female RA patients when compared to male counterparts, but no significant differences were observed in the synovial fluid levels of vitamin E. This suggests that there is an increase in oxidative stress and a decrease in antioxidant defense in RA patients indicating oxidative damage. Keywords: Rheumatoid arthritis, Xanthine oxidase, Malondialdehyde, Superoxide dismutase, Catalase, Vitamin E

https://ijbpas.com/pdf/2019/August/MS_IJBPAS_2019_4777.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.8.4777