ABSTRACT

Candida vaginitis is a common mucosal infectious disease in women caused by Candida albicans infection. The high resistance to antifungal treatmentmakes alternative therapies increasingly necessary. Therefore, this study aimed to investigate the antifungal activity of Mentha piperita essential oil for candidal vaginitis. Mentha piperita essential oil (E.O.) was extracted with n-hexane and a Soxhlet extractor and tested for activities. Thu the agar diffusion method, MIC and MFC were collected in vitro. A dose of Mentha piperita (500 ?g/mouse) E.O. was given intravaginally to vaginal candidiasis mice every two days until day 21. Histological diagnosis using PAS staining was examined in vivo after mice were sacrificed and vaginas excised. The Mentha piperita E.O. showed a high ability to inhibit candidal growth with a 30.7±2.1 mm inhibition zone, with MIC

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https://doi.org/10.31032/IJBPAS/2019/8.7.4763