ABSTRACT

Lavandula pubescens belongs to the family Lamiaceae. This plant commonly grows in Albaha region of Saudi Arabia. It contains many classes of phytoconstituents such as volatile oils, terpenes, flavonoids, phenolics; therefore possesses different biological activities such as antibacterial, antifungal and antidepressant etc. Different extracts (Petroleum ether, chloroform, ethyl acetate, butanol, hydro-methanol and water) were prepared by maceration of dried above ground fragments of Lavandula in different solvents. The volatile components of the pet ether extract were identified by GC/MS which showed the occurrence of ?-isomethyl ionone (45.38%), caryophyllene oxide (29.08%) and Carvacrol (18.08%) as main components. The antimicrobial action of various extracts was assessed using Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Pseudomonas aeuroginosa. The antifungal activity was also tested using fungi Aspergillus flavus and Candida albicans. The results showed that, pet. ether extract exhibited highest activity against E. coli and S. aureus with MIC=32mg/ml. While the cytotoxicity results depicted that, the Inhibitory activity of the hydoalcoholic extract (70%) is maximum and was established as most active with IC50 = 21.4 ± 1.3 ?g/ml against colon carcinoma (HCT-116) cell lines. Key words: Lavandula pubescens, Lamiaceae,Extracts, Antimicrobial, Cytotoxicity

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https://doi.org/10.31032/IJBPAS/2019/8.7.4762