BIOINFORMATICS ANALYSIS TO EXPLORE ISCHEMIC STROKE Authors: Lawrence O. Flowers
ABSTRACT
Stroke continues to be a major health threat around the world. Ischemia-reperfusion events
negatively affect cerebrovascular tissue thus leading to impaired functionality of the brain and
other organs. Dysfunctionality and degeneration of tissues as a result of ischemia-reperfusion
injury leads to chronic diseases and death. With improving bioinformatics technology,
researchers in the field of stroke biology are generating informative studies that have widespread
application. Previous bioinformatics research has provided insight into the role of neuregulin-1
in suppressing neuroinflammatory pathways following focal cerebral ischemia. Functional
studies involving knockout mice and short-interfering RNA (siRNA) knockdown experiments
will be beneficial to determine the therapeutic significance of genetic and protein targets
identified from large-scale bioinformaticsdata.
Keywords: Bioinformatics, Ischemia, Stroke, Neuregulin-1, Neuroprotection
