ABSTRACT

Pb is an early toxicant under the class of environmental pollutants; it has deleterious effects on human being in higher concentration and has no biological role exclusive for human being, it enters inside the human body through different motives but mainly through absorption through GIT, it interplay with variety of intracellular pathways and develop oxidative stress which subsequently plays a malicious role in damaging proteins lipid and DNA. Intracellular damaged me lead to development of carcinogenicity but its major role is to interaction with signaling pathway of heam synthesis, Pb is reported to inhibits all most all steps toward heam production n including this it also cause premature destruction of RBCs result in development of anemia, changed levels of biomarkers, particularly MDA and 4 HNE, of oxidative stress can be helpful in diagnosis and prognosis of anemia by oxidative stress. Keywords: Oxidative stress, Anemia, Lead Toxicity, MDA, 4 HNE

https://ijbpas.com/pdf/2019/June/MS_IJBPAS_2019_4728.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.6.4728