ABSTRACT

The current study was aimed to assess renal and hepatic protective potential of sugar beet pulp extracts(SBPE) against toxicity in rats induced by lead acetate (Pb (C2H3O) 2). A total of 30 rats were pretreated with methanol and sodium hydroxide SBPE (100mg/kg/day) for 15 days, orally followed by intra-peritoneal lead acetate (40mg/kg/day). All rats were sampled on the 16th day for blood and organs. The results revealed significant (p<0.05*) protective effect by reversing fluctuation in opted biomarkers due to lead acetate such as AST (203±14.24 U/L), ALT (95.6±4.36U/L), CR (1.29±0.09mg/dl), BUN (40.1±2.61mg/dl), MDA (265±18.8n,mol/g) and CAT (21.5±0.75?/g). The histopathological examination of SBPE treated groups indicated protective ability by alleviating morphological alteration due to heavy metal into more or less normal morphology. Methanol extract of Sugar beet pulp (SBPME) possesses more antioxidant ability against lead-induced oxidative stress than aqueous extract of Sugar beet pulp (SBPAE) in rats. Keywords: Hepato-renal toxicity, Lead acetate, Sugar beet pulp, Antioxidant, Methanol Extract, Aqueous extract

https://ijbpas.com/pdf/2019/June/MS_IJBPAS_2019_4721.pdf

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https://doi.org/10.31032/IJBPAS/2019/8.6.4721