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ENVIRONMENTAL TOXICITY CAUSED BY HEAVY METALS WITH SPECIAL POSITIONTO ARSENIC, HOW IT INTERFERE WITH PHARMACO-KINETICS OF OTHER ESSENTIAL IONS AND OUTBREAK MAY LEAD TO THOUGHTFUL MODIFICATIONS IN CARDIOVASCULAR SYSTEM AND MALICIOUS ROLE IN DEVELOPMENT OF TYPE 2 DIABETES MELLITUS
Authors: *WAQAS MUHAMMAD1 , SIBGHAT MANSOOR 2, SHOAIB ASIF1, HAROON HABIB2, RABBIA TARIQ3,

ABSTRACT
Arsenic supposed to be dangerous heavy metal present widely in nature; It has the properties to replaces other ions present in human body after its successful absorption from small intestine. Excessive amount may lead to development of oxidative stress; Arsenic induced ROS production and depressed anti-oxidant defense system is the main cause of development of oxidative stress. Elevated MLCK and increased calcium sensitization results in cardiac dysfunctions. While impaired glucose metabolism and increased level of JNK, SPAS and NFkB cause insulin inactivation, resistance and subsequent Diabetes mellitus Type II.

    https://ijbpas.com/pdf/2019/May/MS_IJBPAS_2019_4719.pdf
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https://doi.org/10.31032/IJBPAS/2019/8.5.4719

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