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Physicochemical, Pharmacokinetic and Toxicological Evaluation of 1-cyclopropyl-6-fluoro- N'-isonicotinoyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carbohydrazide: A In Silico Approache
Authors: MAHWISH AKHTAR1* , TANVEER AHMED SIDDIQI2, SYED INAYATULLAH2, SYED AHMAD HASSAN2, SABA NAZ2

ABSTRACT
The aim of the present research is to establish the physicochemical, pharmacokinetics and toxicological properties of a newly designed ciprofloxacin amide derivative by using in silico approach. This compound qualified all the drug likeness rule of Lipinski, Veber, Egan Muegge and Ghose. This novel designed derivative of ciprofloxacin ispredicted good physicochemical and pharmacokinetic properties (absorption, distribution, metabolism, elimination and toxicity). According to the predicted data the developed derivative owns drug-like properties and thenit is synthesized and developed a successful candidate for essential addition against antimicrobial studies. Keywords: Ciprofloxacin analogue, computational study, drug likeness properties, physicochemical properties, pharmacokinetics

    https://ijbpas.com/pdf/2019/May/MS_IJBPAS_2019_4716.pdf
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https://doi.org/10.31032/IJBPAS/2019/8.5.4716

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